![]() First of all, her story was dictated to her son in her native Irish, composed/written down by him and then further edited by Maire Ni Chinneide for publication, it was translated into English and further edited for use as a mandatory text for teaching Irish on the secondary school curriculum, and that, according to historian Finn Dwyer, was modified to reflect the Free State’s version of the quintessential Irish woman. So, there’s a disconnect from the get-go and an almost fivefold detachment to contend with in this autobiography. Like Socrates, she never wrote down a word. I’ve been thinking about varying degrees of detachment recently, particularly in terms of femininity and womanhood and specifically with regard to resoldering the links by reading more women, to forge new bonds with femininity and weave the threads of a female genealogy. ![]() I will leave the stories from that island for you to hear through the voice of the great story-teller. He brother arranged her marriage to a man from one of the Blasket islands. ![]() And it was a future that saw major upheaval in Ireland, the seeds of which were sown in the unrest she describes so well. The important issues of the day - memories of the famine that her parents endured and the ethics of stealing food to stay alive, the Land League, evictions, and emigration - are all interwoven into the life of a young girl as she looks to the future. She remembered that theft years later when she was seventeen on her return home after four years in service in Dingle. When she stole a piece of sweet cake from an old woman in a smoke-filled cottage she knew, as she said, that Someone was watching. It is so poignant and emotionally touching to go back to 1877 and read of a little four year old girl who can't wait to get to school so that she can have her own book filled with coloured pictures. It really needs to be read in Irish, using this translation for reference if you need it, and then the distant voice of your Irish identity will come to you from nearly 150 years ago. I loved it when I studied for the Leaving Cert in 1967 and I still love it.
0 Comments
![]() ![]() In addition to adding the higher-level Ultimate Vault Hunter difficulty mode, the latest update for. Now for anyone in need of the Ultimate Vault Hunter Upgrade Pack 2 here is a key for you (People who purchased/will purchase the game on Humble Bundle or MacGameStore will recieve this key please let others take the key)ĥA30H-5GEH5-XB9FR ĮDIT: The Borderlands 2 Complete Edition Bundle on MacGameStore are Steam keys. Borderlands 2 Cheats PC & Trainer 23 Cheat Codes. Current Prices Historical Low Official Stores: 3. Use the indicated client to activate key and download and play your game. ![]() Head over to one of the trusted game stores from our price comparison and buy cd key at the best price. Then once you login, click Add a Game (located in the bottom Left corner) -> Activate a Product on Steam. The Ultimate Vault Hunter Upgrade Pack 2: Digistruct Peak Challenge adds 11 more levels of character growth, new legendary gear, and the challenging Raid on Digistruct Peak. Compare prices with GG.deals to find the cheapest cd key for Borderlands 2: Ultimate Vault Hunter Upgrade Pack 2 PC. You must login to your Steam Account or create one for free. Compare prices of over 40 stores to find best deals for Borderlands 2: Ultimate Vault Hunter Upgrade Pack 2 in digital distribution. Borderlands 2 Complete Edition is actually on sale for 11.99$ on : įor anyone interested by the game its the best deal you can get (the key works for any OS you dont need a mac to take the deal). STEAM CD KEY : Use the Steam Key Code on Steam Platform to download and play Borderlands 2 Ultimate Vault Hunter Upgrade Pack 2. This guide will tell you how to get the Company Man and what unique special effect it has. ![]() You can see it in full above, restored by YouTuber ManticoreEscapee, along with alternate takes and some behind the scenes footage. The movie initially had a whole other opening reel that showed Plissken and his accomplice robbing the Federal Reserve but the ten minute sequence was cut after test audiences found it confusing. Apart from Russell in arguably his most iconic role (which he had to fight to get since he was at the time typecast as a Disney nice guy) the film also features Donald Pleasance – who had already appeared in Carpenter’s Halloween – as a British-accented US President (in his self-penned character backstory Pleasance imagined the US as a returned British colony), Lee Van Cleef (The “Bad” from The Good The Bad And The Ugly) as warder Hauk (he filmed his entire role in one night), Ernest Borgnine as the gleeful pyromaniac Cabbie, funk and soul (plus South Park) legend Isaac Hayes as criminal overlord The Duke and Harry Dean Stanton as former Plissken gang member Brain. The President has crash-landed inside the prison’s walls and soldier-turned-outlaw Snake Plissken has been forced into a do or die (literally, he has explosives injected into his neck to deter him from fleeing) rescue mission. It is 1997 and the US has been at war with Russia and domestic crime is so rampant that Manhattan has been walled off as a maximum security prison island. The Invisible Man director Leigh Whannell is writing a reboot and may also end up directing so if you haven’t seen the original, well, get off Instagram and go rent it right now. One of the greatest dystopian sci-fi films ever made and an all-time favourite of the INDUSTRIA team, this John Carpenter classic was released 40 years ago today. ![]() ![]() shots all around when a ngga in the buildin, party. ![]() Lady don't worry bout it Baby we'll go out to the floor Anyway they don't know you like I do (to they floor) They'll never know you (Hey! never know) Anyway they don't know you like I do (They don't know) Baby don't worry bout it Lady don't even think about You worry bout the wrong things The wrong things You worry bout the wrong thing Anyway they don't know you like I do They'll never know you Anyway they don't know you like I do They'll never know you. Chorus - Kanye WestWhy are you so paranoid why are you so paranoid why are, why are you so paranoid. It shows that keeping self-serving secrets ends up torturing the offender, possibly more than anyone else involved. KIDS SEE GHOSTS - Cudi Montage Find my back in the cold Trapped in another soul, they can hear me holler Im colder than the game See em all strapped in an. Anyway they don't know you like I do (They don't know) They'll never know you (Never Know) Anyway they don't know you like I do (Never Know) All of the time you wanna complain about the nights alone So now you're here with me Show some gratitude Leave the attitude way back at home Yeah you see em look Baby let em look Give you cold looks cuz we look cold Yeah you heard about all the word of mouth Don't worry about what we can't control All the talk in the world lost in the world 'Til you finally let that thing go You wanna check into the heartbreak hotel But sorry we're closed. B.o.B The protagonist here feels paranoid because of something he’s doing that’s less-than-ethical: he’s dating two women and is afraid his secret will come to light. I walk through the hotel and I walk down the street, and people look at me like I’m fing insane, like I’m Hitler But one day, one day the light will shine through and one day people will. ![]() ![]() They are also not for use on infants.ĭifferent types of warmers: You are probably already aware that you can buy a lot of different types of hand warmers, but many people don’t realize that similar products are available specifically for the toes and the entire foot. It is especially important that they not be used with individuals who have circulation issues or anyone unable to feel the heat, as they can get very hot. Safety: None of the air-activated products are designed to be worn directly on the skin. If you are considering buying large quantities, you may want to keep the expiry date in mind and confirm with the seller what the expiry date is. The expiry date can be anywhere from approximately 2-4 years from purchase (this may vary). Things to be Aware of Before BuyingĮxpiry date: Disposable warmers come with expiry dates. It takes from 10 to 20 minutes for the product to heat up. When the ingredients (usually an iron powder, water, salt, activated charcoal, and vermiculite) in the air-activated toe warmers are exposed to air, they react to produce heat. If you want a cheap, reusable way to keep your feet warm, they are worth considering. They can work well if you have to spend a lot of time outside for work in cold weather and can help keep your feet warm and dry. They are relatively inexpensive and come in three sizes. ![]() They are designed for biking, running, walking, and hiking on cold days. If you like the idea of a toe warmer, but would prefer to have a product that you can reuse, have a look at these Hot Sockees. ![]() Because Mississippi car accident lawyers don’t expect to have access to traffic camera footage, your attorney will be prepared to build your case for compensation using other evidence. You may be disappointed if you were recently injured in a car accident in Mississippi and learned that there is no traffic camera footage of your collision. What if There isn’t Traffic Camera Footage of My Mississippi Car Accident? However, your attorney will be prepared for that scenario since a lack of traffic camera footage is often the norm in car accident lawsuits. Upon learning this, Mississippi victims might be understandably frustrated. When you consider the fact that Mississippi doesn’t allow for red-light or speed cameras, it becomes clear just how unlikely it is for a traffic camera to film or photograph a car accident. If it’s true that there is no available traffic camera footage of your recent crash, an attorney can investigate an accident and uncover other evidence to support your claim. That is why hiring a Jackson car accident lawyer is important if you think a traffic camera filmed your accident. Your request might be delayed or ignored, jeopardizing your access to MDOT traffic camera footage. It can be difficult to contact government agencies, like MDOT, and request information. Remember, these devices are often located on busy highways, not backroads. In fact, if your accident occurred on a local road in Mississippi, it’s almost impossible that an MDOT camera filmed it. For that to happen, you must be in view of an MDOT traffic camera and access the footage immediately after an accident, if it exists at all.Īlthough many MDOT traffic cameras are situated throughout Mississippi, the chances that one filmed your accident aren’t very high. Unfortunately for Mississippi car accident victims, it’s relatively unlikely that a traffic camera will film a collision. What Are the Chances that There is Traffic Camera Footage of My Mississippi Car Accident? Because red-light and speed cameras are not permitted in Mississippi, you cannot access such photos after a car accident. These cameras don’t film footage but take photos of a driver as they run a stoplight or drive past a sensor speeding. Mississippi does not allow for red-light or speed cameras. Acting quickly is important if you think an MDOT camera filmed your accident, so any existing footage isn’t deleted. While it may be difficult for injured victims to contact MDOT to request footage, an experienced Marietta car accident lawyer can do so. MDOT may not store footage for very long, if at all. If an MDOT camera did film your recent Mississippi car accident, it’s important that you hire an attorney. MDOT cameras stream live footage online for staff and drivers to access. These cameras are generally situated at busy intersections and highways to monitor the flow of traffic and weather conditions. Like many states, Mississippi’s Department of Transportation maintains live traffic cameras throughout the state. So, to get traffic camera footage of a car accident, you may have to contact the Mississippi Department of Transportation (MDOT). In Mississippi, only live traffic cameras are allowed. Each state has its own laws regarding the use of such cameras and whether or not they’re permitted. Generally, there are three common types of traffic cameras used throughout the country: live, red-light, and speed cameras. Can I Get Traffic Camera Footage of a Mississippi Car Accident? For a free case evaluation with the Mississippi car accident lawyers at Howe Law, call today at (844) 876-4357. Our attorneys are here to help Mississippi victims hold negligent drivers accountable. An experienced lawyer can use other evidence, like security camera footage and eyewitness testimony, to prove a negligent driver’s fault in a Mississippi car accident lawsuit. Even if there isn’t traffic camera footage of your recent car accident, don’t worry. ![]() That said, it’s important for victims to understand that the chances of a traffic camera filming and storing footage of a crash for a considerable period of time are quite low. If there is traffic camera footage of your recent Mississippi car accident, a lawyer can help you obtain it. Because of that, it’s important for victims to learn how to obtain potential traffic camera footage of a crash in Mississippi. Home » The Howe.Law Injury & Accident Blog » How to Obtain Traffic Camera Footage for a Car Accident in MississippiĪfter a car accident, any evidence showing an at-fault party’s negligence can be helpful to victims, including traffic camera footage. ![]() I lost a lot of sales because I didn’t order enough product. I thought I was a little aggressive with my projections, but they ended up being quite conservative. My first challenge was when I launched my first youth product. What challenges did you face? How did you overcome these? This was incredibly useful as a quick reference to maximize the amount of people my advertising reached in each product segment. In addition, I created my own resource by making an excel spreadsheet that multiplied the reach of the different advertising channels per dollar by the percentage of each segment that used the different channels. I relied on information I had gained from previous marketing courses I had taken, and like I mentioned before, the manual was a critical resource to my success. What resources did you pull on to develop your winning strategy which led you to the top of your course and then top in the Hall of Fame? It really helped me get a better idea of how it all connected. When I didn’t fully understand how a part of the simulation worked, like salesforce management for instance, I would play with different numbers in the single player mode. In addition to that, practicing in the single player simulation gives instant feedback on how different decisions affect growth in the industry. At first, I just read the quick guide, but when I decided to read the full manual, my growth escalated rapidly. Reading the manual is critical to understanding the market in this simulation. How did you familiarize yourself with the simulation? By studying the statistics and graphs in the manual, I was able to determine how much of the budget to allocate to both of these categories, and customize the distribution of funds going to the different channels within advertising and sales promotion. I focused the majority of my budget on advertising and sales promotion. How did you begin implementing that strategy? I also knew I needed to launch a youth focused product before a sports focused product because early in the simulation, the standard product is able to capture some of the sports segment, but it doesn’t capture any of the youth segment. I wanted to gain as much of the market share as I could, as quickly as I could, because I figured it would be more difficult to gain market share as time went on. ![]() ![]() Going into the simulation, my strategy was to increase awareness of my products as much as possible. What was your strategy going into the simulation? By making fewer changes, I was able to reduce variability and know more precisely which changes were affecting my growth. From there, I would typically make one or two changes per product each year. It was critical to gather as much information as I could so I could see which decisions were the most successful, and which areas of my strategy required revision. My decision making process began by analyzing the market from the previous year, comparing growth of all the companies in my world, and studying as much as I could about the industry. What is your decision making process within the simulation? The Smartsims team reached out and interviewed Logun to speak on his experiences, the lessons he learned and advice he would give future students. He landed 10th place in the Music2Go Multi-Player (All Time) Hall of Fame. This week, we’re featuring one of the latest Hall of Fame entrants, Logun Williamson from the University of Utah. ![]() Before everything else, getting ready is the secret of success. YouĬross Reference Used to insert a cross reference link to a DITA resource. Next to a target link to select a new reference for that particular hyperlinked area. Target column displays the target links that exist in the image List of all the areas (shapes) that have been added in the image. The shape table below the Image Map Editor button is a sequential To edit a target link, click the Edit button in the Target column of the Shape Table for the ![]() Information about the interface and the options available. See the Image Map Editor Interface in Web Author section for This opens the Image Map Editor where you can make changes to To edit an existing image map, click the Image Map Editor buttonīelow the image (or select Image Map Editor from the contextual How to Edit an Existing Image Map in Web Author For more information, see the Shape Table section. All three types will open a dialog box that allows you to browse forĪ target resource. You can choose between the following types of links: Cross Target column of the Shape Table for each
In contrast to the normal cell, the tumor cell produces vast amounts of extracellular lactate via aerobic glycolysis ( 15) and consequently generates several disturbances in other cells and the tumor microenvironment ( 16), leading to hypoxia, promotion of angiogenesis, and distant metastasis ( 17, 18). Warburg’s research in the 1920s proved that tumor cells require a high income of glucose to maintain their extremely demanded metabolism activity independently of the oxygen levels, a process known as the Warburg effect or aerobic glycolysis ( 12– 14). These therapies have systemic side effects on patients ( 5), high costs ( 6), and rapid development of drug resistance ( 7– 10), which are some of the limitations that reduce their effectiveness ( 11). In such a scenario, the clinical response rates to conventional treatment based on radiation therapy and/or surgery, chemotherapy ( 3), and immunotherapy ( 4) are poor. The use of cervical cancer screening has helped in an early diagnosis of this disease however, there is still a large population in which the disease is diagnosed in locally advanced stages ( 2). Although its incidence has decreased by approximately 40% in the last decade, it currently remains the second leading cause of cancer-related deaths in women, accounting for an estimated 270,000 women’s lives annually ( 1). Our work provides new evidence of TT against cervical cancer as a promising antineoplastic therapy.ĭespite early detection programs, cervical cancer (CC) is a public health problem that still needs to be solved. Also, we show an anti-migratory activity of the TT, suggesting other targets of the drug combination in the late CC stages.ĭiscussion: These results, together with our former studies, conclude that TT inhibits the mTOR pathway leading to cell death by apoptosis. ![]() In addition, mTOR and S6K phosphorylated proteins were inhibited in the three cell lines. Results: Through flow cytometry, Western blot, and protein microarray experiments, we found TT-induced apoptosis on HeLa, CaSki, and SiHa through the caspase 3 intrinsic pathway, including the critical proapoptotic proteins BAD, BAX, cytochrome-C, and p21. Methods: In this research, we combined the drugs metformin and sodium oxamate with doxorubicin (named triple therapy or TT) based on their mechanism of action and previous investigation of our group against three CC cell lines. In this scenario, drugs used in other pathologies that have antitumor activity, such as metformin and sodium oxamate, are analyzed. Drug repositioning is a strategy to explore known medicines as treatments for other diseases. Therefore, there is a need to continue with the proposal of new therapies. Existing first-line treatments are not enough to avoid cancer recurrence, progression, or metastasis in locally advanced and advanced stages. Treatments used to manage patients diagnosed in the early stages have excellent results as measured by different clinical outcomes. In particular, in 2020, 30,000 deaths of this type of tumor were reported in Latin America. Introduction: Cervical cancer is a worldwide health problem due to the number of deaths caused by this neoplasm. 6Laboratorio de Genómica Funcional, Unidad de Biomedicina, FES-IZTACALA, Universidad Nacional Autónoma de México, Tlalnepantla, Mexico.5CNC - Center for Neuroscience and Cell Biology, CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.4Laboratorio de Hematopoiesis y Leucemia, Unidad de Investigación, Diferenciación Celular y Cáncer, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Iztapalapa, Mexico.3Laboratorio de Genómica, Instituto Nacional de Cancerología, Tlalpan, Mexico. ![]() 2Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México.1Unidad de Bioquímica Guillermo Soberón Acevedo, Instituto de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico.Izamary Delgado-Waldo 1,2, Carlos Contreras-Romero 2,3, Sandra Salazar-Aguilar 4, João Pessoa 5, Irma Mitre-Aguilar 1, Verónica García-Castillo 6, Carlos Pérez-Plasencia 3,6* and Nadia Judith Jacobo-Herrera 1* ![]() You know, so in the traditional browser environment, which is what you'd be doing with Firefox, the number of online cloud services available to you to transfer files is definitely there and they're generally more secure. ![]() ![]() Right? So, the ways to transfer files now for a technical person are just so much better than traditional FTP, which really did not have that level of security.Īnd additionally, if you're really non-technical, you're not having to, you're not dealing with a Linux to local, you know, file copy situation, there's just so many services like Dropbox, Box, Google Drive. You know, frankly, Tim, whenever I'm having to move a file from a Linux server to, you know, somewhere local, probably the go-to for me is to just set up an SSH session, which I might already be in and then use SEP, which is the secure file copy. So, there's just there are just so many newer, better ways of doing it, not the least of which is SFTP, or SSHFTP, FTP/ TLS. And so, the reasons that Mozilla is stating their intent to deprecate it is they say that it is an old and fundamentally insecure protocol, that to bring it up to contemporary security standards would be pointless considering that you can accomplish all the same things other ways and those other ways are almost all of how it's done and I think what they're doing now is they're trying to signal well in advance that this is going to go away to get people who are still dependent on FTP to move to those other methods so that when they turn it off, they're not going to break any more people than they have to. Like even before you had reliable use of web pages, you could be using FTP and in the early days, certainly the early days of the world-wide web, you would get lots of FTP addresses. You know, it's, one of those things, it's one of those, it's one of those file transfer protocols, FTP that, of course, was used for an awfully long time and, in fact, it was a great, great tool back in the earlier days of the internet, and right up until today.Ībsolutely. So, today, we want to talk about a recent announcement from Mozilla, that Firefox, that in the Firefox browser, they are going to deprecate support for FTP. Root Causes 97: Firefox to Deprecate Support for FTP Episode Transcript Lightly edited for flow and brevity. |